GDF11 Treatment Attenuates the Recovery of Skeletal Muscle Function After Injury in Older Rats

Loss of skeletal muscle mass and function results in loss of mobility for elderly patients. Novel therapies that can protect and/or restore muscle function during aging would have profound effects on the quality of life for this population. Growth differentiation factor 11 (GDF11) has been proposed...

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Bibliographic Details
Published in:The AAPS journal 2017-03, Vol.19 (2), p.431-437
Main Authors: Zhou, Yu, Sharma, Neel, Dukes, David, Myzithras, Maria B., Gupta, Priyanka, Khalil, Ashraf, Kahn, Julius, Ahlberg, Jennifer S., Hayes, David B., Franti, Michael, Criswell, Tracy
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Bone Morphogenetic Proteins - administration & dosage
Bone Morphogenetic Proteins - toxicity
Disease Models, Animal
Fibrosis
Growth Differentiation Factors - administration & dosage
Growth Differentiation Factors - toxicity
Humans
Male
Muscle, Skeletal - injuries
Muscle, Skeletal - metabolism
Pharmacology/Toxicology
Pharmacy
Quality of Life
Rats
Rats, Inbred Lew
Regeneration - physiology
Research Article
Theme: Recent Advances in Musculoskeletal Tissue Engineering
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Summary:Loss of skeletal muscle mass and function results in loss of mobility for elderly patients. Novel therapies that can protect and/or restore muscle function during aging would have profound effects on the quality of life for this population. Growth differentiation factor 11 (GDF11) has been proposed as a “youthful” circulating factor that can restore cardiac, neural, and skeletal muscle functions in aging animals. However, conflicting data has been recently published that casts doubt on these assertions. We used a complex rat model of skeletal muscle injury that physiologically mimics injuries seen in patients; to investigate the ability of GDF11 and to enhance skeletal muscle regeneration after injury in older rats. Our data showed that GDF11 treatment resulted in a significant increase in tissue fibrosis, accompanied by attenuated functional recovery, as compared to animals treated with vehicle alone. GDF11 impaired the recovery of skeletal muscle function in older rats after injury.
ISSN:1550-7416
1550-7416
DOI:10.1208/s12248-016-0024-x