Noninvasive Swansea criteria are valuable alternatives for diagnosing acute fatty liver of pregnancy in a Chinese population

• Published in: The journal of maternal-fetal & neonatal medicine 2017-12, Vol.30 (24), p.2951-2955
• Main Authors: Wang, Shan, Li, Shan-Ling, Cao, Yan-Xia, Li, Yan-Ping, Meng, Jin-Lai, Wang, Xie-Tong
• Format: Article
• Language: English
• Subjects: Acute fatty liver of pregnancy; Adult; China; diagnose; Diagnosis, Differential; Early Diagnosis; Fatty Liver - diagnosis; Female; Gestational Age; Humans; Liver Function Tests - methods; Medicine, Chinese Traditional - methods; noninvasive; Pregnancy; Pregnancy Complications - diagnosis; Prenatal Diagnosis - methods; Retrospective Studies; Sensitivity and Specificity; Swansea criteria; Young Adult
• ISSN: 1476-7058; 1476-4954
• DOI: 10.1080/14767058.2016.1269316

Background: This study aims to assess the diagnostic and prognostic value of Swansea criteria in diagnosing acute fatty liver of pregnancy (AFLP) in a Chinese population. Methods: A retrospective study was conducted on 52 Chinese women diagnosed with AFLP. All selected cases were reassessed using the Swansea criteria with special focus on the noninvasive criteria, since performing a liver biopsy for this indication is rare in a Chinese population. Results: Ninety point four percent of patients fulfilled five or more of the Swansea criteria. Thirty-one cases were positive for six or more Swansea criteria, but there were no significance differences between patients when using a cutoff criteria 6. When patients were positive for less than seven criteria, frequency of stillbirth, continuous blood purification (CBP) treatment, hysterectomy, and postpartum hemorrhage were not increased. However, patients who were positive for seven or more criteria had a significantly higher risk of stillbirth and a higher rate of CBP treatment (p