Association of a gain‐of‐function variant in LGR4 with central obesity

Objective To determine the relationship of the gain‐of‐function variant A750T in leucine‐rich repeat containing G protein‐coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes. Methods The LGR4 A750T (c.2248 G > A) variant was detected by Sanger sequencing in a discovery...

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Published in:Obesity (Silver Spring, Md.) Md.), 2017-01, Vol.25 (1), p.252-260
Main Authors: Zou, Yaoyu, Ning, Tinglu, Shi, Juan, Chen, Maopei, Ding, Lin, Huang, Ya, Kauderer, Sophie, Xu, Min, Cui, Bin, Bi, Yufang, Liu, Simin, Hong, Jie, Liu, Ruixin, Ning, Guang, Wang, Jiqiu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Glucose - metabolism
Blood Pressure
Body Mass Index
China
Cholesterol - blood
Genetic Variation
Genotyping Techniques
Glucose
Humans
Insulin - blood
Insulin resistance
Insulin Resistance - genetics
Intra-Abdominal Fat
Linear Models
Obesity
Obesity, Abdominal - epidemiology
Obesity, Abdominal - genetics
Receptors, G-Protein-Coupled - genetics
Reproducibility of Results
Studies
Tomography, X-Ray Computed
Waist Circumference
Waist-Hip Ratio
Young Adult
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Summary:Objective To determine the relationship of the gain‐of‐function variant A750T in leucine‐rich repeat containing G protein‐coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes. Methods The LGR4 A750T (c.2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community‐based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis. Results LGR4 A750T was significantly correlated with waist circumference (P = 0.030) and waist‐to‐height ratio (P < 0.001) in the young cohort (N = 594) and with waist‐to‐hip ratio (P = 0.013) in the community population (N = 1067). Combined analysis showed a significant correlation of the variant with waist circumference (P < 0.001) and waist‐to‐hip ratio (P = 0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area (P = 0.004) and was associated with 2‐h plasma insulin (P = 0.009) and the Matsuda index (P = 0.027) after an oral glucose tolerance test in young subjects with obesity. Conclusions The LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21704