Possible Levofloxacin-Induced Acute Hepatocellular Injury in a Patient with Chronic Obstructive Lung Disease

Levofloxacin is one of the most commonly prescribed antibiotics for both inpatient and outpatient care of respiratory tract infection. It is generally well tolerated, and it has an excellent safety profile. We report a case of severe acute liver toxicity that apparently complicated intravenous admin...

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Bibliographic Details
Published in:Clinical infectious diseases 2001-12, Vol.33 (12), p.2088-2090
Main Authors: Karim, Anita, Ahmed, Shahid, Rossoff, Leonard J., Siddiqui, Rina K., Steinberg, Harry N.
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Anti-Infective Agents - adverse effects
Anticoagulants
Biological and medical sciences
Brief Reports
Chemical and Drug Induced Liver Injury
Drug toxicity and drugs side effects treatment
Female
Fluoroquinolones
Hepatotoxicity
Humans
Infusions, Intravenous
Levofloxacin
Liver
Liver - drug effects
Liver - injuries
Liver Diseases - etiology
Liver Function Tests
Medical sciences
Medications
Ofloxacin - adverse effects
Oxygen
Pharmacology. Drug treatments
Physical trauma
Prothrombin time
Pulmonary Disease, Chronic Obstructive - complications
Test ranges
Toxicity: digestive system
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Summary:Levofloxacin is one of the most commonly prescribed antibiotics for both inpatient and outpatient care of respiratory tract infection. It is generally well tolerated, and it has an excellent safety profile. We report a case of severe acute liver toxicity that apparently complicated intravenous administration of levofloxacin, which resolved after discontinuation of the drug.
ISSN:1058-4838
1537-6591
DOI:10.1086/338156