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Possible Levofloxacin-Induced Acute Hepatocellular Injury in a Patient with Chronic Obstructive Lung Disease
Levofloxacin is one of the most commonly prescribed antibiotics for both inpatient and outpatient care of respiratory tract infection. It is generally well tolerated, and it has an excellent safety profile. We report a case of severe acute liver toxicity that apparently complicated intravenous admin...
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Published in: | Clinical infectious diseases 2001-12, Vol.33 (12), p.2088-2090 |
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container_end_page | 2090 |
container_issue | 12 |
container_start_page | 2088 |
container_title | Clinical infectious diseases |
container_volume | 33 |
creator | Karim, Anita Ahmed, Shahid Rossoff, Leonard J. Siddiqui, Rina K. Steinberg, Harry N. |
description | Levofloxacin is one of the most commonly prescribed antibiotics for both inpatient and outpatient care of respiratory tract infection. It is generally well tolerated, and it has an excellent safety profile. We report a case of severe acute liver toxicity that apparently complicated intravenous administration of levofloxacin, which resolved after discontinuation of the drug. |
doi_str_mv | 10.1086/338156 |
format | article |
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It is generally well tolerated, and it has an excellent safety profile. We report a case of severe acute liver toxicity that apparently complicated intravenous administration of levofloxacin, which resolved after discontinuation of the drug.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/338156</identifier><identifier>PMID: 11712098</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acute Disease ; Aged ; Anti-Infective Agents - adverse effects ; Anticoagulants ; Biological and medical sciences ; Brief Reports ; Chemical and Drug Induced Liver Injury ; Drug toxicity and drugs side effects treatment ; Female ; Fluoroquinolones ; Hepatotoxicity ; Humans ; Infusions, Intravenous ; Levofloxacin ; Liver ; Liver - drug effects ; Liver - injuries ; Liver Diseases - etiology ; Liver Function Tests ; Medical sciences ; Medications ; Ofloxacin - adverse effects ; Oxygen ; Pharmacology. 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Drug treatments</subject><subject>Physical trauma</subject><subject>Prothrombin time</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Test ranges</subject><subject>Toxicity: digestive system</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp10MtuEzEUBmALgWgp8AQImQXsBny_LKtwSVBEswAJdWN5PB7qMBkHX0r79kw0UbNiZUvn03_sH4CXGL3HSIkPlCrMxSNwjjmVjeAaP57uiKuGKarOwLOctwhhrBB_Cs4wlpggrc7BsIk5h3bwcO1vYz_EO-vC2KzGrjrfwUtXi4dLv7clOj8MdbAJrsZtTfcwjNDCjS3BjwX-DeUGLm5SHIODV20uqboSbqfYOv6CH0P2Nvvn4Elvh-xfHM8L8OPzp--LZbO--rJaXK4bx6QqjZROSE77jjvdos4h5pjGTgqheiKdtpJ1rW6Z1B0hvW513-JOIE6wIlQLRS_Auzl3n-Kf6nMxu5APz7ejjzUbrJjQXMgTdGmqIfne7FPY2XRvMDKHXs3c6wRfHxNru_PdiR2LnMDbI7DZ2aFPdnQhnxylmjJGJvdmdrHu_7_s1Wy2ucT0oBhTRPPDqmYeh1z83cPYpt9m-pLkZvnz2kjyjWy-XgvD6T_gWKGv</recordid><startdate>20011215</startdate><enddate>20011215</enddate><creator>Karim, Anita</creator><creator>Ahmed, Shahid</creator><creator>Rossoff, Leonard J.</creator><creator>Siddiqui, Rina K.</creator><creator>Steinberg, Harry N.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20011215</creationdate><title>Possible Levofloxacin-Induced Acute Hepatocellular Injury in a Patient with Chronic Obstructive Lung Disease</title><author>Karim, Anita ; Ahmed, Shahid ; Rossoff, Leonard J. ; Siddiqui, Rina K. ; Steinberg, Harry N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-77c6753fd5c9b0dc04c491c7668f27c9a74db9b479d22f9b9fb1d605218239683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Anti-Infective Agents - adverse effects</topic><topic>Anticoagulants</topic><topic>Biological and medical sciences</topic><topic>Brief Reports</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Hepatotoxicity</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Levofloxacin</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - injuries</topic><topic>Liver Diseases - etiology</topic><topic>Liver Function Tests</topic><topic>Medical sciences</topic><topic>Medications</topic><topic>Ofloxacin - adverse effects</topic><topic>Oxygen</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical trauma</topic><topic>Prothrombin time</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Test ranges</topic><topic>Toxicity: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karim, Anita</creatorcontrib><creatorcontrib>Ahmed, Shahid</creatorcontrib><creatorcontrib>Rossoff, Leonard J.</creatorcontrib><creatorcontrib>Siddiqui, Rina K.</creatorcontrib><creatorcontrib>Steinberg, Harry N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karim, Anita</au><au>Ahmed, Shahid</au><au>Rossoff, Leonard J.</au><au>Siddiqui, Rina K.</au><au>Steinberg, Harry N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible Levofloxacin-Induced Acute Hepatocellular Injury in a Patient with Chronic Obstructive Lung Disease</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2001-12-15</date><risdate>2001</risdate><volume>33</volume><issue>12</issue><spage>2088</spage><epage>2090</epage><pages>2088-2090</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Levofloxacin is one of the most commonly prescribed antibiotics for both inpatient and outpatient care of respiratory tract infection. 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source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
subjects | Acute Disease Aged Anti-Infective Agents - adverse effects Anticoagulants Biological and medical sciences Brief Reports Chemical and Drug Induced Liver Injury Drug toxicity and drugs side effects treatment Female Fluoroquinolones Hepatotoxicity Humans Infusions, Intravenous Levofloxacin Liver Liver - drug effects Liver - injuries Liver Diseases - etiology Liver Function Tests Medical sciences Medications Ofloxacin - adverse effects Oxygen Pharmacology. Drug treatments Physical trauma Prothrombin time Pulmonary Disease, Chronic Obstructive - complications Test ranges Toxicity: digestive system |
title | Possible Levofloxacin-Induced Acute Hepatocellular Injury in a Patient with Chronic Obstructive Lung Disease |
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