Effects of occupational exposure to styrene on expression of adhesion molecule on leukocytes

Styrene is an indispensable chemical extensively used in plastic and synthetic rubber industries. Styrene is known to produce various types of hepatotoxic, neurotoxic, and genotoxic effects. Styrene may be immunotoxic by both direct and indirect mechanisms. Measurement of adhesion molecules is a new...

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Bibliographic Details
Published in:Human & experimental toxicology 2002-05, Vol.21 (5), p.235-240
Main Authors: Jahnová, E, Tulinská, J, Weissová, S, Dusinská, M, Fuortes, L
Format: Article
Language:English
Subjects:
Adult
Antigens
Artificial rubber
Biological and medical sciences
Breath tests
Cell adhesion & migration
Cell Adhesion Molecules - biosynthesis
Cell Adhesion Molecules - blood
Chemical and industrial products toxicology. Toxic occupational diseases
Clinical medicine
Environmental Monitoring
Female
Flow Cytometry
Granulocytes
Humans
Immune system
Immune System - drug effects
Inhalation Exposure
Intercellular Adhesion Molecule-1 - blood
L-Selectin - blood
Laboratory animals
Leukocytes
Leukocytes - drug effects
Leukocytes - metabolism
Lymphocytes
Male
Medical sciences
Neurotoxicity
Occupational Exposure - adverse effects
Solvents
Styrene - adverse effects
Toxicology
Workers
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Summary:Styrene is an indispensable chemical extensively used in plastic and synthetic rubber industries. Styrene is known to produce various types of hepatotoxic, neurotoxic, and genotoxic effects. Styrene may be immunotoxic by both direct and indirect mechanisms. Measurement of adhesion molecules is a new tool for the investigation of immune system modulation. The aim of this study was to evaluate the association of the expression of the adhesion molecules CD11a, CD11b, CD18, CD54, CD49d, and CD62L in white blood cells and levels of soluble adhesion molecules ICAM-1 and L-selectin in serum with occupational exposure to styrene. Analyses by flow cytometry revealed elevated levels of most of the assessed adhesion molecules on surfaces of lymphocytes, monocytes, and granulocytes. Expression of the adhesion receptor antigens CD11a on lymphocytes, CD11b on monocytes, and CD18 on granulocytes were unaffected. Workers exposed to styrene had decreased concentrations of sICAM-1 and no changes in concentrations of sL-selectin. Styrene exposure appears to increase activation of the immune system and alter leukocyte adherence. This interaction is a critical first step in immune stimulation and leukocyte–endothelial interaction.
ISSN:0960-3271
1477-0903
DOI:10.1191/0960327102ht251oa