Synthesis of potential buprenorphine intermediates by selective microbial N- and O-demethylation

A group of filamentous fungi from the genus Cunninghamella have been identified as potential biocatalysts in the generation of potential buprenorphine intermediates. A simple batch fermentation procedure results in the formation of dealkylated alkaloid compounds that are readily available for analys...

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Bibliographic Details
Published in:Biotechnology letters 2002-08, Vol.24 (15), p.1291-1294
Main Authors: ABEL, Anthony M, CORNELL, Andrew J, DAVIS, J. Alf, PAYLOR, Michael
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Chemical synthesis
Fermentation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Microbiology
Other active biomolecules
Production of active biomolecules
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Summary:A group of filamentous fungi from the genus Cunninghamella have been identified as potential biocatalysts in the generation of potential buprenorphine intermediates. A simple batch fermentation procedure results in the formation of dealkylated alkaloid compounds that are readily available for analysis and further chemical modification.[PUBLICATION ABSTRACT]
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1016218211300