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Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study

Whether soy intake is associated with a decreased risk of cardiovascular disease (CVD) remains unclear. A traditional Japanese soy food, natto, contains a potent fibrinolytic enzyme. However, its relation to CVD has not been studied. We aimed to examine the association of CVD mortality with the inta...

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Published in:The American journal of clinical nutrition 2017-02, Vol.105 (2), p.426-431
Main Authors: Nagata, Chisato, Wada, Keiko, Tamura, Takashi, Konishi, Kie, Goto, Yuko, Koda, Sachi, Kawachi, Toshiyuki, Tsuji, Michiko, Nakamura, Kozue
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description Whether soy intake is associated with a decreased risk of cardiovascular disease (CVD) remains unclear. A traditional Japanese soy food, natto, contains a potent fibrinolytic enzyme. However, its relation to CVD has not been studied. We aimed to examine the association of CVD mortality with the intake of natto, soy protein, and soy isoflavones in a population-based cohort study in Japan. The study included 13,355 male and 15,724 female Takayama Study participants aged ≥35 y. At recruitment in 1992, each subject was administered a validated semiquantitative food-frequency questionnaire. Deaths from CVD were ascertained over 16 y. A total of 1678 deaths from CVD including 677 stroke and 308 ischemic heart disease occurred during follow-up. The highest quartile of natto intake compared with the lowest intake was significantly associated with a decreased risk of mortality from total CVD after control for covariates: the HR was 0.75 (95% CI: 0.64, 0.88, P-trend = 0.0004). There were no significant associations between the risk of mortality from total CVD and intakes of total soy protein, total soy isoflavone, and soy protein or soy isoflavone from soy foods other than natto. The highest quartiles of total soy protein and natto intakes were significantly associated with a decreased risk of mortality from total stroke (HR = 0.75, 95% CI: 0.57, 0.99, P-trend = 0.03 and HR = 0.68, 95% CI: 0.52, 0.88, P-trend = 0.0004, respectively). The highest quartile of natto intake was also significantly associated with a decreased risk of mortality from ischemic stroke (HR = 0.67, 95% CI:0.47, 0.95, P-trend = 0.03). Data suggest that natto intake may contribute to the reduction of CVD mortality.
doi_str_mv 10.3945/ajcn.116.137281
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source ScienceDirect Journals
subjects Adult
Adults
Aged
Asian People
Cardiovascular disease
Cardiovascular Diseases - mortality
Cohort Studies
Diet
Endpoint Determination
Enzymes
Female
Follow-Up Studies
Humans
Isoflavones - administration & dosage
Japan
Linear Models
Male
Middle Aged
Nutrition Assessment
Prospective Studies
Risk Factors
Soy Foods
Soybean Proteins - administration & dosage
Soybeans
Surveys and Questionnaires
title Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study
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