Fulminant liver failure in a neonate

Neonatal acute liver disease is relatively rare, with multiple different aetiologies including congenital infections, metabolic disorders, gestational alloimmune liver disease, haemophagocytic lymphohistiocytosis, and ischaemic injury. We report a case of neonatal liver failure in a preterm, growth‐...

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Bibliographic Details
Published in:Journal of paediatrics and child health 2016-03, Vol.52 (3), p.338-341
Main Authors: Clarke, Naomi E, Gilby, Damien, Savoia, Helen, Oliver, Mark R, Rogerson, Sheryle
Format: Article
Language:English
Subjects:
Hyperglycemia
Liver cirrhosis
Liver diseases
Metabolic disorders
Newborn babies
Pediatrics
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Summary:Neonatal acute liver disease is relatively rare, with multiple different aetiologies including congenital infections, metabolic disorders, gestational alloimmune liver disease, haemophagocytic lymphohistiocytosis, and ischaemic injury. We report a case of neonatal liver failure in a preterm, growth‐restricted infant, who underwent extensive investigation and was clinically diagnosed with gestational alloimmune liver disease, which was confirmed on post‐mortem examination. We then discuss management of neonatal liver failure and gestational alloimmune liver disease, including maternal management in future pregnancies.
ISSN:1034-4810
1440-1754
1440-1754
DOI:10.1111/jpc.13090