Air pollutant–mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway

[...]we confirmed that the barrier-destabilizing effect of PM at 4 hours was not due to cell death as assessed by lactate dehydrogenase release using 500 μg PM, a dose even above that at which the barrier-destabilizing effect of PM was observed (see Fig E2 in this article's Online Repository a...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-12, Vol.138 (6), p.1736-1738.e4
Main Authors: London, Nyall R., MD, PhD, Tharakan, Anuj, BS, Rule, Ana M., PhD, Lane, Andrew P., MD, Biswal, Shyam, PhD, Ramanathan, Murugappan, MD
Format: Article
Language:English
Subjects:
Air Pollutants - adverse effects
Air pollution
Air Pollution - adverse effects
Allergy and Immunology
Animals
Asthma
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Humans
Inflammation
Localization
NF-E2-Related Factor 2 - metabolism
Particulate Matter - adverse effects
Pollutants
Rodents
Small intestine
Zonula Occludens-1 Protein - metabolism
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Summary:[...]we confirmed that the barrier-destabilizing effect of PM at 4 hours was not due to cell death as assessed by lactate dehydrogenase release using 500 μg PM, a dose even above that at which the barrier-destabilizing effect of PM was observed (see Fig E2 in this article's Online Repository at www.jacionline.org). Interestingly, SFN is found naturally in cruciferous vegetables such as broccoli, cabbage, or Brussel sprouts. [...]additional studies may demonstrate dietary advantages protecting against environmental-induced airway disease.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.06.027