Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis

TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs...

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Bibliographic Details
Published in:International immunology 2016-12, Vol.28 (12), p.605-609
Main Authors: Tsurusaki, Satoshi, Tahara-Hanaoka, Satoko, Shibagaki, Shohei, Miyake, Shota, Imai, Masamichi, Shibayama, Shiro, Kubo, Masato, Shibuya, Akira
Format: Article
Language:English
Subjects:
Animals
Dermatitis - immunology
Dermatitis - pathology
Mast Cells - cytology
Mast Cells - immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Immunologic - deficiency
Receptors, Immunologic - immunology
Toll-Like Receptor 2 - antagonists & inhibitors
Toll-Like Receptor 2 - immunology
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Summary:TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas-TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis.
ISSN:0953-8178
1460-2377
DOI:10.1093/intimm/dxw046