Successful T-cell Replete Hematopoietic Stem Cell Boost Without Conditioning for Late Graft Failure

Abstract Late graft failure is a rare but significant complication after allogeneic stem cell transplantation, which is often complicated by severe infections. We report a case of late graft failure, which was successfully treated with a T-cell replete hematopoietic stem cell boost without condition...

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Bibliographic Details
Published in:Transplantation proceedings 2016-11, Vol.48 (9), p.3225-3226
Main Authors: Tsutsumi, Y, Tateno, T, Ito, S, Shiratori, S, Teshima, T
Format: Article
Language:English
Subjects:
Female
Graft vs Host Disease - surgery
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic Stem Cells
Humans
Immunosuppressive Agents - therapeutic use
Male
Reoperation
Surgery
Transplantation Conditioning
Transplantation, Homologous
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Summary:Abstract Late graft failure is a rare but significant complication after allogeneic stem cell transplantation, which is often complicated by severe infections. We report a case of late graft failure, which was successfully treated with a T-cell replete hematopoietic stem cell boost without conditioning that induced rapid engraftment and relieved the patient of infection. Discontinuation of immunosuppressants and nilotinib administration suppressed the host cells. Achieving full donor chimerism allowed us to administer a peripheral blood stem cell boost without conditioning.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2016.06.035