Evaluation of Pregnancy Outcomes After Liver Transplantation

Abstract Liver transplantation is increasing worldwide. Pregnancy after liver transplantation is considered to be well tolerated with favorable neonatal outcomes in cases of stable and sufficient graft function. In this study, our aim was to determine pregnancy and neonatal outcomes of patients afte...

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Bibliographic Details
Published in:Transplantation proceedings 2016-12, Vol.48 (10), p.3373-3377
Main Authors: Akarsu, M, Unek, T, Avcu, A, Ozbilgin, M, Egeli, T, Astarcioglu, I
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Female
Humans
Hypertension - epidemiology
Hypertension - etiology
Infant, Newborn
Live Birth - epidemiology
Liver Transplantation - adverse effects
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - etiology
Premature Birth - epidemiology
Premature Birth - etiology
Retrospective Studies
Surgery
Turkey - epidemiology
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Summary:Abstract Liver transplantation is increasing worldwide. Pregnancy after liver transplantation is considered to be well tolerated with favorable neonatal outcomes in cases of stable and sufficient graft function. In this study, our aim was to determine pregnancy and neonatal outcomes of patients after liver transplantation. Data for patients who had been followed-up by the liver transplantation clinic at the Dokuz Eylül University Medical Faculty Hospital, Turkey, between 2002 and 2016, and who had pregnancy after the transplantation were evaluated retrospectively. The earliest post-transplantation conception occurred after 22 months and the latest conception occurred after 108 months (mean, 55.4 months). Twenty-one pregnancies concluded with live births (100%). The mean birth week was 37.09. The earliest birth occurred at 27 weeks and the latest at 40 weeks. Mean birth weight was 2993 g (10th to 25th percentiles). No pregnancy-induced hypertension, pre-eclampsia, or gestational diabetes were observed in any patient. Five pregnancies concluded with premature birth. In conclusion, several complications may occur during pregnancy (such as hypertension or pre-eclampsia, etc) in patients with liver transplantation, but it seems that pregnancy has good effects on graft functions and the neonatal outcomes are favorable.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2016.09.033