Effects of different components of the extracellular matrix on endothelialization

The endothelialization of cardiovascular prostheses is known to improve their haemocompatibility. As such body-foreign materials often do not endothelialize spontaneously. A lot of in vitro studies are ongoing how endothelialization of biomaterials can be improved. In this study the influence of dif...

Full description

Saved in:
Bibliographic Details
Published in:Clinical hemorheology and microcirculation 2016-01, Vol.64 (4), p.867-874
Main Authors: Krüger-Genge, A., Fuhrmann, R., Jung, F., Franke, R.P.
Format: Article
Language:English
Subjects:
Cells, Cultured
Endothelial Cells - drug effects
Endothelium, Vascular - drug effects
Extracellular Matrix - drug effects
Humans
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The endothelialization of cardiovascular prostheses is known to improve their haemocompatibility. As such body-foreign materials often do not endothelialize spontaneously. A lot of in vitro studies are ongoing how endothelialization of biomaterials can be improved. In this study the influence of different components of a tissue-typical extracellular matrix (ECM) like laminin, fibronectin or gelatin on the formation of an endothelial cell monolayer and on the shear resistance of adherent cells on these substrates was studied. The study revealed that the density of human venous endothelial cells (HUVEC) monolayers differed markedly between cells grown on a natural ECM and cells grown on singularized components of an ECM (p 
ISSN:1386-0291
1875-8622
DOI:10.3233/CH-168051