Blood Concentration of Milnacipran in a Case of a Fatal Automobile Accident

A fatal automobile accident involving milnacipran and ethyl alcohol is reported. The drug was identified and quantitated in blood by high-performance liquid chromatography-diode-array detection. The concentration of milnacipran in peripheral blood was 3.15 µg/mL exceeded 10.5 times the therapeutic c...

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Bibliographic Details
Published in:Journal of analytical toxicology 2002-03, Vol.26 (2), p.123-126
Main Authors: Rop, Pok P., Sournac, Marie H., Burle, Joelle, Fornaris, Monique, Coiffait, Philippe E.
Format: Article
Language:English
Subjects:
Accidents, Traffic
Adult
Alcohol Drinking - adverse effects
Analysis
Antidepressive Agents - adverse effects
Antidepressive Agents - blood
Biological and medical sciences
Chromatography, High Pressure Liquid
Cyclopropanes - adverse effects
Cyclopropanes - blood
Drug Interactions
Ethanol - adverse effects
Ethanol - blood
Fatal Outcome
Female
Forensic Medicine - methods
General pharmacology
Humans
Medical sciences
Milnacipran
Pharmacology. Drug treatments
Substance Abuse Detection - methods
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Summary:A fatal automobile accident involving milnacipran and ethyl alcohol is reported. The drug was identified and quantitated in blood by high-performance liquid chromatography-diode-array detection. The concentration of milnacipran in peripheral blood was 3.15 µg/mL exceeded 10.5 times the therapeutic concentration. The blood ethyl alcohol level was 1.3 g/L.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/26.2.123