Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)

Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evid...

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Bibliographic Details
Published in:Bulletin of entomological research 2001-08, Vol.91 (4), p.265-272
Main Authors: Brooke, B.D., Kloke, G., Hunt, R.H., Koekemoer, L.L., Tem, E.A., Taylor, M.E., Small, G., Hemingway, J., Coetzee, M.
Format: Article
Language:English
Subjects:
Agrochemicals
Animals
Anopheles - drug effects
Anopheles - enzymology
Bioassays
Biological and medical sciences
Biological Assay
Detoxification
Female
Fundamental and applied biological sciences. Psychology
Insecticide Resistance
Insecticides
Insecticides - pharmacology
Malaria
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
Mosquitoes
Nitriles
Oxidoreductases - metabolism
Pesticide Synergists - pharmacology
Piperonyl Butoxide - pharmacology
Propoxur - pharmacology
Public health
Pyrethrins - pharmacology
Pyrethroids
Vector-borne diseases
Vectors. Intermediate hosts
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Summary:Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evidence of resistance to pyrethroid insecticides. Insecticide exposure, synergist and biochemical assays conducted on A. funestus suggested that elevated levels of mixed function oxidases were responsible for the detoxification of pyrethroids in resistant mosquitoes in these areas. The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur.
ISSN:0007-4853
1475-2670
DOI:10.1079/BER2001108