STI and beyond: the prospects of boosting anti-HIV immune responses

Twenty years into the HIV epidemic, highly active antiretroviral therapy (HAART) represents the only effective intervention to control HIV-1 disease progression. However, the prospect of life-long treatment with HAART is challenging given cumulative drug toxicities, difficulties with adherence to co...

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Bibliographic Details
Published in:Trends in Immunology 2002-09, Vol.23 (9), p.456-460
Main Authors: Allen, Todd M, Kelleher, Anthony D, Zaunders, John, Walker, Bruce D
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active - methods
Chronic Disease
Drug therapy
HIV
HIV - immunology
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - therapy
Human immunodeficiency virus
Humans
Immune system
Infections
Mortality
Zidovudine - administration & dosage
Zidovudine - therapeutic use
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Summary:Twenty years into the HIV epidemic, highly active antiretroviral therapy (HAART) represents the only effective intervention to control HIV-1 disease progression. However, the prospect of life-long treatment with HAART is challenging given cumulative drug toxicities, difficulties with adherence to complicated regimens and the looming emergence of drug-resistant viruses. The challenges are even greater in resource-poor settings where costs and logistical problems with delivery represent formidable obstacles. Alternative approaches to long-term control of viral replication and disease progression are clearly needed. HAART is the only way to control HIV-1 progression, however, with cumulative drug toxicities and the looming emergence of drug-resistant viruses among the future problems, alternative approaches are clearly needed.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(02)02297-4