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Relationship between blood lead levels and renal function in lead battery workers
The aim of this study was to investigate the correlation between blood lead (PbB) levels and renal function indices of blood-urea nitrogen (BUN), serum creatinine (SC) and uric acid (UA) among lead battery workers with exposure to lead. A total of 229 workers of both genders from two lead battery fa...
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| Published in: | International archives of occupational and environmental health 2002-11, Vol.75 (8), p.569-575 |
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| Main Authors: | , , , , , , |
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| container_end_page | 575 |
| container_issue | 8 |
| container_start_page | 569 |
| container_title | International archives of occupational and environmental health |
| container_volume | 75 |
| creator | WANG, Ven-Shing LEE, Ming-Tsung CHIOU, Jyh-Yann GUU, Chiam-Fang WU, Chin-Ching WU, Trong-Neng LAI, Jim-Shoung |
| description | The aim of this study was to investigate the correlation between blood lead (PbB) levels and renal function indices of blood-urea nitrogen (BUN), serum creatinine (SC) and uric acid (UA) among lead battery workers with exposure to lead.
A total of 229 workers of both genders from two lead battery factories were recruited in this cross-sectional study. The personal airborne and blood samples were collected on the same day. The airborne lead (PbA) and PbB levels, and individual renal function parameters were measured and statistically analyzed.
A positive correlation between PbB levels and individual renal function index of BUN, SC, and UA was found ( P |
| doi_str_mv | 10.1007/s00420-002-0362-0 |
| format | article |
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A total of 229 workers of both genders from two lead battery factories were recruited in this cross-sectional study. The personal airborne and blood samples were collected on the same day. The airborne lead (PbA) and PbB levels, and individual renal function parameters were measured and statistically analyzed.
A positive correlation between PbB levels and individual renal function index of BUN, SC, and UA was found ( P<0.01). The PbB levels and renal function indices showed significant difference between male and female workers. Based on a multiple regression model, an increment of 10 micro g/dl PbB produced an increase of 0.62 mg/dl BUN, after being adjusted for work duration and age, and an increase of 0.085 mg/dl UA, after being adjusted for gender and body weight. Workers with PbB <or=60 microg/dl and >60 microg/dl showed a positive dose-effect relationship with significant difference in BUN ( P<0.001) and UA ( P<0.05), and the percentage of workers with BUN and UA over the reference value also showed an increasing trend.
Blood-urea nitrogen and uric acid could be considered as suitable prognostic indicators of renal dysfunction in lead-exposed workers. Our results showed that PbB levels higher than 60 micro g/dl had increasing chances of inducing adverse renal effects.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-002-0362-0</identifier><identifier>PMID: 12373319</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cross-Sectional Studies ; Dose-Response Relationship, Drug ; Female ; Humans ; Industry ; Kidney - drug effects ; Kidney - physiology ; Kidney - physiopathology ; Kidney Function Tests ; Lead - adverse effects ; Lead - blood ; Male ; Medical sciences ; Metals and various inorganic compounds ; Middle Aged ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Surveys and Questionnaires ; Taiwan ; Toxicology</subject><ispartof>International archives of occupational and environmental health, 2002-11, Vol.75 (8), p.569-575</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-e25c8cf19c568f90aca49acbfae4590b03973264f7fcedb2e8ad4de6701f1c5c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13986898$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12373319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, Ven-Shing</creatorcontrib><creatorcontrib>LEE, Ming-Tsung</creatorcontrib><creatorcontrib>CHIOU, Jyh-Yann</creatorcontrib><creatorcontrib>GUU, Chiam-Fang</creatorcontrib><creatorcontrib>WU, Chin-Ching</creatorcontrib><creatorcontrib>WU, Trong-Neng</creatorcontrib><creatorcontrib>LAI, Jim-Shoung</creatorcontrib><title>Relationship between blood lead levels and renal function in lead battery workers</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><description>The aim of this study was to investigate the correlation between blood lead (PbB) levels and renal function indices of blood-urea nitrogen (BUN), serum creatinine (SC) and uric acid (UA) among lead battery workers with exposure to lead.
A total of 229 workers of both genders from two lead battery factories were recruited in this cross-sectional study. The personal airborne and blood samples were collected on the same day. The airborne lead (PbA) and PbB levels, and individual renal function parameters were measured and statistically analyzed.
A positive correlation between PbB levels and individual renal function index of BUN, SC, and UA was found ( P<0.01). The PbB levels and renal function indices showed significant difference between male and female workers. Based on a multiple regression model, an increment of 10 micro g/dl PbB produced an increase of 0.62 mg/dl BUN, after being adjusted for work duration and age, and an increase of 0.085 mg/dl UA, after being adjusted for gender and body weight. Workers with PbB <or=60 microg/dl and >60 microg/dl showed a positive dose-effect relationship with significant difference in BUN ( P<0.001) and UA ( P<0.05), and the percentage of workers with BUN and UA over the reference value also showed an increasing trend.
Blood-urea nitrogen and uric acid could be considered as suitable prognostic indicators of renal dysfunction in lead-exposed workers. Our results showed that PbB levels higher than 60 micro g/dl had increasing chances of inducing adverse renal effects.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cross-Sectional Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Industry</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Kidney - physiopathology</subject><subject>Kidney Function Tests</subject><subject>Lead - adverse effects</subject><subject>Lead - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Surveys and Questionnaires</subject><subject>Taiwan</subject><subject>Toxicology</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpFkMtOwzAQRS0EoqXwAWyQN7ALjB9J7CWqeEmVEAjWkeOMRcBNip1S9e9JlEjd3FnMuXdxCLlkcMsA8rsIIDkkADwBkfVxROZMCp4wLrNjMgch-y8TbEbOYvwGYHmWi1MyY1zkQjA9J2_v6E1Xt038qje0xG6H2NDSt21FPZoh_tBHapqKBmyMp27b2KFA62YkStN1GPZ014YfDPGcnDjjI15Md0E-Hx8-ls_J6vXpZXm_SqzkskuQp1ZZx7RNM-U0GGukNrZ0BmWqoQShc8Ez6XJnsSo5KlPJCrMcmGM2tWJBbsbdTWh_txi7Yl1Hi96bBtttLJiSWjGte5CNoA1tjAFdsQn12oR9waAYPBajx6L3WAwe-1iQq2l8W66xOjQmcT1wPQEmWuNdMI2t44ETWmVKK_EP7tN8Bg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>WANG, Ven-Shing</creator><creator>LEE, Ming-Tsung</creator><creator>CHIOU, Jyh-Yann</creator><creator>GUU, Chiam-Fang</creator><creator>WU, Chin-Ching</creator><creator>WU, Trong-Neng</creator><creator>LAI, Jim-Shoung</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20021101</creationdate><title>Relationship between blood lead levels and renal function in lead battery workers</title><author>WANG, Ven-Shing ; LEE, Ming-Tsung ; CHIOU, Jyh-Yann ; GUU, Chiam-Fang ; WU, Chin-Ching ; WU, Trong-Neng ; LAI, Jim-Shoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-e25c8cf19c568f90aca49acbfae4590b03973264f7fcedb2e8ad4de6701f1c5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cross-Sectional Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Industry</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Kidney - physiopathology</topic><topic>Kidney Function Tests</topic><topic>Lead - adverse effects</topic><topic>Lead - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Surveys and Questionnaires</topic><topic>Taiwan</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, Ven-Shing</creatorcontrib><creatorcontrib>LEE, Ming-Tsung</creatorcontrib><creatorcontrib>CHIOU, Jyh-Yann</creatorcontrib><creatorcontrib>GUU, Chiam-Fang</creatorcontrib><creatorcontrib>WU, Chin-Ching</creatorcontrib><creatorcontrib>WU, Trong-Neng</creatorcontrib><creatorcontrib>LAI, Jim-Shoung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, Ven-Shing</au><au>LEE, Ming-Tsung</au><au>CHIOU, Jyh-Yann</au><au>GUU, Chiam-Fang</au><au>WU, Chin-Ching</au><au>WU, Trong-Neng</au><au>LAI, Jim-Shoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between blood lead levels and renal function in lead battery workers</atitle><jtitle>International archives of occupational and environmental health</jtitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>75</volume><issue>8</issue><spage>569</spage><epage>575</epage><pages>569-575</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>The aim of this study was to investigate the correlation between blood lead (PbB) levels and renal function indices of blood-urea nitrogen (BUN), serum creatinine (SC) and uric acid (UA) among lead battery workers with exposure to lead.
A total of 229 workers of both genders from two lead battery factories were recruited in this cross-sectional study. The personal airborne and blood samples were collected on the same day. The airborne lead (PbA) and PbB levels, and individual renal function parameters were measured and statistically analyzed.
A positive correlation between PbB levels and individual renal function index of BUN, SC, and UA was found ( P<0.01). The PbB levels and renal function indices showed significant difference between male and female workers. Based on a multiple regression model, an increment of 10 micro g/dl PbB produced an increase of 0.62 mg/dl BUN, after being adjusted for work duration and age, and an increase of 0.085 mg/dl UA, after being adjusted for gender and body weight. Workers with PbB <or=60 microg/dl and >60 microg/dl showed a positive dose-effect relationship with significant difference in BUN ( P<0.001) and UA ( P<0.05), and the percentage of workers with BUN and UA over the reference value also showed an increasing trend.
Blood-urea nitrogen and uric acid could be considered as suitable prognostic indicators of renal dysfunction in lead-exposed workers. Our results showed that PbB levels higher than 60 micro g/dl had increasing chances of inducing adverse renal effects.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12373319</pmid><doi>10.1007/s00420-002-0362-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cross-Sectional Studies Dose-Response Relationship, Drug Female Humans Industry Kidney - drug effects Kidney - physiology Kidney - physiopathology Kidney Function Tests Lead - adverse effects Lead - blood Male Medical sciences Metals and various inorganic compounds Middle Aged Occupational Exposure - adverse effects Occupational Exposure - analysis Surveys and Questionnaires Taiwan Toxicology |
| title | Relationship between blood lead levels and renal function in lead battery workers |
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