Implications of hormesis for industrial hygiene

This paper considers hormesis as a valid and potentially valuable alternative hypothesis for low-dose response in the context of occupational health risk assessment. It outlines the current occupational risk assessment paradigm and its use of high-dose toxicological data in setting occupational expo...

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Bibliographic Details
Published in:Human & experimental toxicology 2002-07, Vol.21 (7), p.385-389
Main Authors: Jayjock, M A, Lewis, P G
Format: Article
Language:English
Subjects:
Animals
Dose-Response Relationship, Drug
Health risk assessment
Health risks
Hormesis
Humans
Hygiene
No-Observed-Adverse-Effect Level
Occupational Exposure - adverse effects
Occupational Health
Occupational safety
Population
Statistical power
Toxicity
Toxicology
Citations: Items that this one cites
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Summary:This paper considers hormesis as a valid and potentially valuable alternative hypothesis for low-dose response in the context of occupational health risk assessment. It outlines the current occupational risk assessment paradigm and its use of high-dose toxicological data in setting occupational exposure limits (OELs). This present effort is a call to science to investigate the potential promise of hormesis in providing prima facie experimental evidence for a low-dose threshold of toxic effect to chemical agents. The scientific effort and advancement advised in this piece could also lead to experimentally validated quantitative estimates of the toxic effect extant at occupational exposures in the region of the OEL.
ISSN:0960-3271
1477-0903
DOI:10.1191/0960327102ht264oa