A Piperidine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae

• Published in: Journal of agricultural and food chemistry 2002-06, Vol.50 (13), p.3765-3767
• Main Authors: Yang, Young-Cheol, Lee, Sang-Guei, Lee, Hee-Kwon, Kim, Moo-Key, Lee, Sang-Hyun, Lee, Hoi-Seon
• Format: Article
• Language: English
• Subjects: Aedes - growth & development; Alkaloids - chemistry; Alkaloids - isolation & purification; Animals; Biological and medical sciences; Fruit - chemistry; Fundamental and applied biological sciences. Psychology; Insecticides - chemistry; Insecticides - isolation & purification; Larva; Medically important nuisances and vectors, pests of stored products and materials: population survey and control; Methanol; Nuisances; Piperaceae - chemistry; Piperidines; Plant Extracts - chemistry
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf011708f

Mosquito larvicidal activity of Piper longum fruit-derived materials against the fourth-instar larvae of Aedes aegypti was examined. A crude methanol extract of P. longum fruits was found to be active against the larvae, and the hexane fraction of the methanol extract showed a strong larvicidal activity of 100% mortality. The biologically active component of P. longum fruits was characterized as pipernonaline by spectroscopic analyses. The LC50 value of pipernonaline was 0.25 mg/L. The toxicity of pipernonaline is comparable to that of pirimiphos-methyl as a mosquito larvicide. In tests with available components derived from P. longum, no activity was observed with piperettine, piperine, or piperlongumine. Keywords: Aedes aegypti; Piper longum; pipernonaline; mosquito larvicidal activity