The ventilatory response to hypoxia

We do not challenge the 'classic' theory of peripheral-chemoreceptor-mediated HVR. However, this offers no insight into the mediators of the time-domain components of HVR, such as ventilatory short-term potentiation (VSTP). VSTP is critical to respiratory-system stability and is unrelated...

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Bibliographic Details
Published in:Nature (London) 2002-10, Vol.419 (6908), p.686-686
Main Authors: Berger, Philip J., Skuza, Elizabeth M., Brodecky, Vojta, Wilkinson, Malcolm H.
Format: Article
Language:English
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Summary:We do not challenge the 'classic' theory of peripheral-chemoreceptor-mediated HVR. However, this offers no insight into the mediators of the time-domain components of HVR, such as ventilatory short-term potentiation (VSTP). VSTP is critical to respiratory-system stability and is unrelated to the activity of the peripheral chemoreceptor, so other factors may have a role in HVR. One such factor involves SNO signalling in brainstem neurons. SNOs could be formed by neuronal nitric oxide synthase (NOS, activated by afferents from peripheral chemoreceptors) and by erythrocyte deoxygenation. Indeed, erythrocyte deoxygenation could be signalled to peripheral chemoreceptors through SNO formation.
ISSN:0028-0836
1476-4687
DOI:10.1038/419686a