New insights into spotty calcification and plaque rupture in acute coronary syndrome: an optical coherence tomography study

• Published in: Heart and vessels 2016-12, Vol.31 (12), p.1915-1922
• Main Authors: Sakaguchi, Mikumo, Hasegawa, Takao, Ehara, Shoichi, Matsumoto, Kenji, Mizutani, Kazuki, Iguchi, Tomokazu, Ishii, Hideshi, Nakagawa, Masashi, Shimada, Kenei, Yoshiyama, Minoru
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - diagnostic imaging; Aged; Aged, 80 and over; Biomedical Engineering and Bioengineering; Calcification; Cardiac Surgery; Cardiology; Cardiovascular disease; Chi-Square Distribution; Coronary Artery Disease - diagnostic imaging; Coronary Vessels - diagnostic imaging; Female; Humans; Logistic Models; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Odds Ratio; Original Article; Plaque, Atherosclerotic; Predictive Value of Tests; Prospective Studies; Rupture, Spontaneous; Tomography; Tomography, Optical Coherence; Vascular Calcification - diagnostic imaging; Vascular Surgery
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-016-0820-3

Although recent optical coherence tomography (OCT) studies have focused on spotty calcification, whether there were any characteristics in the concomitant existence of calcification and plaque rupture remains unknown. The aim of the present study was to investigate the characteristics of spotty calcification in acute coronary syndrome (ACS) patients with or without plaque rupture, using OCT. This study enrolled 98 consecutive patients with ACS. OCT image acquisitions were performed in the culprit lesions, and patients were divided into the plaque rupture group ( n  = 38) and the non-rupture group ( n  = 60). The frequency of spotty calcification ( p  = 0.006), thin-capped fibroatheroma ( p  = 0.012), macrophage infiltration ( p  = 0.022), and the number of spotty calcification per patient ( p