Maternal cardiac adaptation to subsequent pregnancy in formerly pre‐eclamptic women according to recurrence of pre‐eclampsia

ABSTRACT Objectives Left‐ventricular remodeling in women with pre‐eclampsia (PE) is concentric rather than eccentric, and tends to persist postpartum, particularly after early‐onset PE. This study was designed to determine whether prepregnancy cardiac geometry and function along with cardiac adaptat...

Full description

Saved in:
Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2016-01, Vol.47 (1), p.96-103
Main Authors: Ghossein‐Doha, C., Spaanderman, M. E. A., Al Doulah, R., Van Kuijk, S. M., Peeters, L. L. H.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
cardiac adaptation
Case-Control Studies
Echocardiography
Echocardiography, Doppler
Female
Heart Rate
Heart Ventricles - diagnostic imaging
Humans
left ventricular geometry
left ventricular mass
Odds Ratio
Pre-Eclampsia - diagnostic imaging
Pre-Eclampsia - epidemiology
Pregnancy
pre‐eclampsia
Recurrence
recurrent pre‐eclampsia
Stroke Volume
Vascular Resistance
Ventricular Remodeling
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Objectives Left‐ventricular remodeling in women with pre‐eclampsia (PE) is concentric rather than eccentric, and tends to persist postpartum, particularly after early‐onset PE. This study was designed to determine whether prepregnancy cardiac geometry and function along with cardiac adaptation to the subsequent pregnancy in former early‐onset PE patients differs between those who do and those who do not develop recurrent PE later on in their second pregnancy. Methods In 51 women with a history of early‐onset PE, we performed serial cardiac ultrasound examinations and recorded automated measurements of blood pressure/heart rate before pregnancy and again at three consecutive times in the first half of their subsequent pregnancy. From the hospital records, we retrieved information on pregnancy outcome. We compared intergroup differences in cardiac indices using independent samples t‐test, and intergroup differences in prepregnant cardiac ultrasound indices and subsequent pregnancy‐induced cardiac adaptive response using repeated‐measures ANOVA. Results PE recurred in 14/51 (27%) women. Preconception, the recurrent‐PE group differed from the non‐recurrent‐PE group by having a lower left‐ventricular mass (LVM) index (28 vs 32 g/m2.7, P 
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.15752