Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis

Highlights • The role of the pneumococcal LytB protein as a vaccine antigen is described. • The immunological response after immunization with LytB is characterized. • Antibodies to LytB activate complement-mediated immunity and phagocytosis. • Vaccination with LytB increased bacterial clearance and...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2016-12, Vol.34 (50), p.6148-6157
Main Authors: Corsini, Bruno, Aguinagalde, Leire, Ruiz, Susana, Domenech, Mirian, Antequera, María Luisa, Fenoll, Asunción, García, Pedro, García, Ernesto, Yuste, Jose
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Allergy and Immunology
Aluminum Hydroxide - administration & dosage
Animal models
Animals
Antibodies, Bacterial - blood
Bacteria
Biofilms
Cell division
Cell wall hydrolase
Complement immunity
Complement System Proteins - metabolism
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Enzymes
Experiments
Female
Immunization
Immunoassays
Immunoglobulin G - blood
Immunoglobulins
Immunologic Factors - metabolism
LytB
Male
Mice, Inbred BALB C
Mortality
N-Acetylmuramoyl-L-alanine Amidase - administration & dosage
N-Acetylmuramoyl-L-alanine Amidase - immunology
Neutrophils - immunology
Phagocytosis
Pneumococcal Infections - immunology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - administration & dosage
Pneumococcal Vaccines - immunology
Pneumonia
Pneumonia, Bacterial - immunology
Pneumonia, Bacterial - prevention & control
Proteins
Sepsis
Sepsis - immunology
Sepsis - prevention & control
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
Studies
Treatment Outcome
Vaccine protein
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • The role of the pneumococcal LytB protein as a vaccine antigen is described. • The immunological response after immunization with LytB is characterized. • Antibodies to LytB activate complement-mediated immunity and phagocytosis. • Vaccination with LytB increased bacterial clearance and induced protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.11.001