Expanding the phenotype of CRB2 mutations - A new ciliopathy syndrome?

Recessive CRB2 mutations were recently reported to cause both steroid resistant nephrotic syndrome and prenatal onset ventriculomegaly with kidney disease. We report two Ashkenazi Jewish siblings clinically diagnosed with ciliopathy. Both presented with severe congenital hydrocephalus and mild urina...

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Bibliographic Details
Published in:Clinical genetics 2016-12, Vol.90 (6), p.540-544
Main Authors: Jaron, R., Rosenfeld, N., Zahdeh, F., Carmi, S., Beni-Adani, L., Doviner, V., Picard, E., Segel, R., Zeligson, S., Carmel, L., Renbaum, P., Levy-Lahad, E.
Format: Article
Language:English
Subjects:
Carrier Proteins - genetics
Child
Child, Preschool
Ciliopathies - diagnostic imaging
Ciliopathies - genetics
Ciliopathies - physiopathology
ciliopathy
CRB2
Female
Genetic disorders
Genotype & phenotype
Heterozygote
Humans
hydrocephalus
Jews - genetics
Male
Membrane Proteins - genetics
Microtubule-Associated Proteins - genetics
Mutation
Pedigree
Phenotype
polarity protein
pulmonary hypoplasia
renal disease
Siblings
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Summary:Recessive CRB2 mutations were recently reported to cause both steroid resistant nephrotic syndrome and prenatal onset ventriculomegaly with kidney disease. We report two Ashkenazi Jewish siblings clinically diagnosed with ciliopathy. Both presented with severe congenital hydrocephalus and mild urinary tract anomalies. One affected sibling also has lung hypoplasia and heart defects. Exome sequencing and further CRB2 analysis revealed that both siblings are compound heterozygotes for CRB2 mutations p.N800K and p.Gly1036Alafs*43, and heterozygous for a deleterious splice variant in the ciliopathy gene TTCB21. CRB2 is a polarity protein which plays a role in ciliogenesis and ciliary function. Biallelic CRB2 mutations in animal models result in phenotypes consistent with ciliopathy. This report expands the phenotype of CRB2 mutations to include lung hypoplasia and uretero‐pelvic renal anomalies, and confirms cardiac malformation as a feature. We suggest that CRB2‐associated disease is a new ciliopathy syndrome with possible digenic/triallelic inheritance, as observed in other ciliopathies. Clinically, CRB2 should be assessed when ciliopathy is suspected, especially in Ashkenazi Jews, where we found that p.N800K carrier frequency is 1 of 64. Patients harboring CRB2 mutations should be tested for the complete range of ciliopathy manifestations.
ISSN:0009-9163
1399-0004
DOI:10.1111/cge.12764