Phagocytosis of bone marrow derived macrophages is controlled by Phosphoinositide 3-kinase γ

Highlights • Phosphoinositide 3-kinase γ (PI3Kγ) expression is induced to in response to lipopolysaccharide (LPS). • LPS activates PI3Kγ as demonstrated by induction of PIP3 und activation of protein kinase B (AKT). • PI3Kγ is acting as a mediator of macrophage phagocytosis. • Phagocytosis of LPS ac...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 2016-12, Vol.180, p.9-16
Main Authors: Kresinsky, Anne, Schneble, Nadine, Schmidt, Caroline, Frister, Adrian, Bauer, Reinhard, Wetzker, Reinhard, Müller, Jörg P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Bone Marrow - metabolism
Bone Marrow - physiology
cAMP
Cell Line
Knock out
Lipid-kinase
Macrophages - metabolism
Macrophages - physiology
Mice
Mice, Knockout
Phagocytosis - physiology
Phosphatidylinositol 3-Kinases - metabolism
Phosphodiesterase
PI3Kγ
Signal Transduction - physiology
Signalling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Phosphoinositide 3-kinase γ (PI3Kγ) expression is induced to in response to lipopolysaccharide (LPS). • LPS activates PI3Kγ as demonstrated by induction of PIP3 und activation of protein kinase B (AKT). • PI3Kγ is acting as a mediator of macrophage phagocytosis. • Phagocytosis of LPS activated BMDM was reduced in PI3Kγ depleted cells. • Phosphoinositide 3-kinases alpha, beta or delta do not affect phagocytic activity of macrophages. • The PI3Kγ protein has a lipid-kinase independent role on phagocytosis. • PI3Kγ protein mediated suppression of cAMP signaling is critical for efficient phagocytosis of macrophages
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.09.014