Adverse effect of smoking on prognosis in human papillomavirus-associated oropharyngeal carcinoma

• Published in: Head & neck 2016-12, Vol.38 (12), p.1780-1787
• Main Authors: Liskamp, Carmen P., Janssens, Geert O., Bussink, Johan, Melchers, Willem J., Kaanders, Johannes H., Verhoef, Cornelia G.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Cohort Studies; Combined Modality Therapy; Databases, Factual; Disease-Free Survival; Female; human papillomavirus (HPV); Humans; intensity-modulated radiotherapy (IMRT); Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; oropharyngeal carcinoma; Oropharyngeal Neoplasms - mortality; Oropharyngeal Neoplasms - pathology; Oropharyngeal Neoplasms - therapy; Oropharyngeal Neoplasms - virology; Papillomaviridae; Papillomaviridae - isolation & purification; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; Prognosis; Proportional Hazards Models; radiotherapy; Retrospective Studies; Risk Assessment; smoking; Smoking - adverse effects; Smoking - epidemiology; Survival Analysis
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.24516

Background The purpose of this retrospective study was to identify prognostic factors in a cohort of patients with oropharyngeal carcinoma treated with intensity‐modulated radiotherapy (IMRT). Methods Medical records of 142 patients treated with (chemo)radiotherapy between September 2005 and September 2011 were reviewed and the human papillomavirus (HPV) status was determined by polymerase chain reaction (PCR) analysis. Potential prognostic factors for 3‐year locoregional control and overall survival (OS) were evaluated. Results HPV‐positive patients (n = 82) had locoregional control and OS of 78% and 79%, respectively. Significant prognostic factors on multivariate analysis were smoking (p = .03) for locoregional control and OS, and comorbidity (p = .04) for OS. Further stratification was done according to smoking behavior in HPV‐positive patients. Locoregional control in current smokers was 67% compared to 86% in never smokers and former smokers, respectively (p = .02). Conclusion Smoking was the only modifiable prognostic factor in HPV‐positive patients. Therefore, active stop‐smoking programs must be integrated in the routine management of patients to maximize treatment results. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1780–1787, 2016