Management of the clinically N0 neck in squamous cell carcinoma of the maxillary alveolus and hard palate

Background The purpose of this study was to evaluate active surveillance strategy in the clinically negative neck in maxillary squamous cell carcinoma (SCC). Methods One hundred fourteen consecutive patients diagnosed with oral maxillary SCC were analyzed retrospectively from 3 centers in The Nether...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2016-12, Vol.38 (12), p.1794-1798
Main Authors: Os, Alejandra D. van, Karakullukcu, Baris, Leemans, C. René, Halmos, Gyorgy B., Roodenburg, Jan L. N., Weert, Stijn van, Karagozoglu, K. Hakki, Witjes, Max J. H.
Format: Article
Language:English
Subjects:
active surveillance
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cohort Studies
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Male
maxillary cancer
Maxillary Neoplasms - mortality
Maxillary Neoplasms - pathology
Maxillary Neoplasms - therapy
Middle Aged
Neck - pathology
neck dissection
Neoplasm Invasiveness - pathology
Neoplasm Staging
Netherlands
Palatal Neoplasms - mortality
Palatal Neoplasms - pathology
Palatal Neoplasms - therapy
Prognosis
Retrospective Studies
Risk Assessment
Survival Analysis
Watchful Waiting - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The purpose of this study was to evaluate active surveillance strategy in the clinically negative neck in maxillary squamous cell carcinoma (SCC). Methods One hundred fourteen consecutive patients diagnosed with oral maxillary SCC were analyzed retrospectively from 3 centers in The Netherlands. Analysis parameters included regional disease‐free survival of N0 patients stratified for T classification, elective radiotherapy (RT) of the neck; and overall survival of the whole cohort, stratified by N classification; salvage neck surgery rates. Results Within the N0 cohort, 26.0% of the patients developed neck metastasis in the follow‐up visits. Regional recurrence was not related to T classification or postoperative RT of the neck. Regional and locoregional recurrence were associated with diminished overall survival (p < .05). Regional metastasis was operable in 22 of 26 cases (85%). Only 1 patient presented with inoperable neck metastasis without local recurrence. Conclusion Watchful waiting was feasible in this cohort. If meticulous follow‐up is not available, elective neck dissection is recommended. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1794–1798, 2016
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24511