Comparison of in vitro bioactivity of chicken prolactin and mammalian lactogenic hormones

Highlights • Large scale preparation of recombinant chicken prolactin (chPRL). • Evaluation of prolactins and other lactogenic hormones activity using heterologous and homologous bioassays. • The homologous assay are valid for predicting the activity of species-specific lactogenic hormones in vivo a...

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Bibliographic Details
Published in:General and comparative endocrinology 2017-01, Vol.240, p.27-34
Main Authors: Ocłoń, Ewa, Leśniak-Walentyn, Agnieszka, Solomon, Gili, Shpilman, Michal, Hrabia, Anna, Gertler, Arieh
Format: Article
Language:English
Subjects:
Animals
Bioactivity
Chicken
Chickens - metabolism
Endocrinology & Metabolism
Escherichia coli
Humans
Mammals
Prolactin
Prolactin - metabolism
Rabbits
Recombinant
Sheep
Species Specificity
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Summary:Highlights • Large scale preparation of recombinant chicken prolactin (chPRL). • Evaluation of prolactins and other lactogenic hormones activity using heterologous and homologous bioassays. • The homologous assay are valid for predicting the activity of species-specific lactogenic hormones in vivo activity, whereas heterologous bioassays might be misleading.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2016.09.008