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Effectiveness of prolonged clopidogrel-based dual antiplatelet therapy after drug-eluting stent implantation: Evidence-based meta-analysis

The use of drug-eluting stents (DESs) for patients with coronary artery disease is widespread. DESs have been associated with a lower rate of repeat revascularization, death, and myocardial infarction compared with bare metal stents. However, DESs can lead to a prothrombotic environment in the coron...

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Bibliographic Details
Published in:Herz 2015-08, Vol.40 (5), p.795-802
Main Authors: Liu, Changzhi, Liu, Mao, Chen, Dezhu, Liu, Haifeng, Jiang, Qianhua, Lu, Jianhai, Zuo, Liuer
Format: Article
Language:English
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Summary:The use of drug-eluting stents (DESs) for patients with coronary artery disease is widespread. DESs have been associated with a lower rate of repeat revascularization, death, and myocardial infarction compared with bare metal stents. However, DESs can lead to a prothrombotic environment in the coronary arteries, resulting in a higher rate of thrombotic events. To counteract this, dual-antiplatelet therapy (DAPT) consisting of aspirin and clopidogrel is recommended. Currently, there are no clear guidelines on the duration of DAPT. We therefore conducted a meta-analysis to assess the effectiveness of prolonged DAPT after DES implantation.
ISSN:0340-9937
1615-6692
DOI:10.1007/s00059-015-4304-5