Perinatal Brain Injury is Accompanied by Disturbances in Expression of SLC Protein Superfamily in Endotheliocytes of Hippocampal Microvessels

• Published in: Bulletin of experimental biology and medicine 2016-10, Vol.161 (6), p.770-774
• Main Authors: Morgun, A. V., Kuvacheva, N. V., Khilazheva, E. D., Pozhilenkova, E. A., Gorina, Ya. V., Malinovskaya, N. A., Komleva, Yu. K., Lopatina, O. L., Panina, Yu. A., Gasymly, E. D., Salmina, A. B.
• Format: Article
• Language: English
• Subjects: Age Factors; Analysis; Animals; Animals, Newborn; Anxiety, Separation - complications; Anxiety, Separation - genetics; Anxiety, Separation - metabolism; Anxiety, Separation - pathology; Astrocytes - metabolism; Astrocytes - pathology; Biomedical and Life Sciences; Biomedicine; Biophysics and Biochemistry; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - pathology; Brain; Brain injuries; Cell Biology; Endothelial Cells - metabolism; Endothelial Cells - pathology; Female; Gene Expression Regulation; Glucose metabolism; Glucose Transporter Type 4 - genetics; Glucose Transporter Type 4 - metabolism; Glutamate; Glycogen Synthase Kinase 3 - genetics; Glycogen Synthase Kinase 3 - metabolism; Hippocampus - blood supply; Hippocampus - metabolism; Hippocampus - pathology; Humans; Hypoxia - complications; Hypoxia - genetics; Hypoxia - metabolism; Hypoxia - pathology; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Internal Medicine; Laboratory Medicine; Male; Metabolites; Microvessels - metabolism; Microvessels - pathology; Neurons; Neurons - metabolism; Neurons - pathology; Neurovascular Coupling; Pathology; Rats; Rats, Wistar; Stress, Psychological - complications; Stress, Psychological - genetics; Stress, Psychological - metabolism; Stress, Psychological - pathology; Transport proteins
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3506-z

The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.