Atypical teratoid/rhabdoid tumor arising in a malignant glioma

Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irr...

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Bibliographic Details
Published in:Pediatric blood & cancer 2017-01, Vol.64 (1), p.96-99
Main Authors: Bozzai, Barbara, Hasselblatt, Martin, Turányi, Eszter, Frühwald, Michael C., Siebert, Reiner, Bens, Susanne, Schneppenheim, Reinhard, Kool, Marcel, Stelczer, Gábor, Hortobágyi, Tibor, Hauser, Peter
Format: Article
Language:English
Subjects:
atypical teratoid/rhabdoid tumor
Child, Preschool
Combined Modality Therapy
Female
glioblastoma
Glioma - pathology
Glioma - therapy
Hematology
Humans
irradiation
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - etiology
Neoplasm Staging
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - etiology
Oncology
Pediatrics
pleomorphic xanthoastrocytoma
Prognosis
Rhabdoid Tumor - diagnosis
Rhabdoid Tumor - etiology
temozolomide
Teratoma - diagnosis
Teratoma - etiology
therapy‐induced secondary tumor
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Summary:Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.26173