Effect of chronic exercise on metabolism of obese MSG-treated rats after lipectomy

• Published in: International Journal of Obesity 2002-08, Vol.26, p.82-82
• Main Authors: Habitante, CA, Oyama, L M, Damaso, A R, Estadella, D, do Nascimento, CMO
• Format: Article
• Language: English
• ISSN: 0307-0565

Lipectomy and liposuction have been used as adjuvants in the treatment of obesity in humans. Some works have reported regeneration of adipose tissue after lipectomy. Since chronic exercise could attenuated the obesity, the aim of this study was to evaluate the effect of long term parcial lipectomy (45 days) associated with exercise in the MSG obese rats body weight (BW) and the Ret and Epi relative weight and LR. Also, it has been determined the glucose (Glu), insulin (In) and leptin (Lep) serum concentrations. At 3 months of age, MSG rats were divided in 4 groups: lipectomized (L) or sham-operated (Sh), exercised (E) or sedentary (S). Around of 27% of Ret (1.20 plus or minus 0.08g) and 46% of Epi (2.16 plus or minus 0.25g) were removed. One week after surgery, the LE and ShE animals were submitted to an exercise protocol during 45 days (swimming, 90min/day). After this, the animals were killed 1h after an i.p injection of 3 mCi super(3)H sub(2)0 for determination of LR ( mu mol of super(3)H sub(2)0 incorporated into lipid/g of tissue .h). The trunk blood was collected for Glu (mg/dl), In ( mu U/ml) and Lep (ng/mL) analysis. Ret and Epi were removed and weighed. Exercise decreased BW gain and Lep in both L and Sh rats. The relative weight of Ret, Glu and In were similar among groups. The Epi relative weight was lower in LS and LE than in ShS and ShE. The Ret LR was higher in LS than in ShS, ShE and LE, and the Epi LR was lower in LE than in LS. These results demonstrated a metabolic difference between Ret and Epi after partial lipectomy in obese MSG. Also suggested that after long term lipectomy the Ret regrowth could occur in part by an increase in lipid synthesis. The exercise was uneffective to prevent Ret regrowth. Supported by FAPESP.