Intestinal Intravascular Large B-cell Lymphoma Mimicking Ulcerative Colitis with Secondary Membranoproliferative Glomerulonephritis

A 47-year-old woman with ulcerative colitis (UC) was admitted to our hospital for renal dysfunction and progressive anemia. Colonoscopy revealed intestinal lesions and pathological findings showed intravascular large B-cell lymphoma (IVLBCL). According to the polymerase chain reaction analysis of se...

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Bibliographic Details
Published in:Internal Medicine 2016/09/01, Vol.55(17), pp.2475-2481
Main Authors: Kaneyuki, Daisuke, Komeno, Yukiko, Yoshimoto, Hiroshi, Yoshimura, Naoki, Iihara, Kuniko, Ryu, Tomiko
Format: Article
Language:English
Subjects:
Biopsy
Colitis, Ulcerative - diagnosis
Diagnosis, Differential
Female
Glomerulonephritis, Membranoproliferative - etiology
Humans
intestinal lymphoma
Intestinal Neoplasms - complications
Intestinal Neoplasms - diagnosis
Intestinal Neoplasms - drug therapy
intravascular large B-cell lymphoma (IVLBCL)
Lymphoma, Large B-Cell, Diffuse - complications
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - drug therapy
membranoproliferative glomerulonephritis (MPGN)
Middle Aged
Nephrotic Syndrome - chemically induced
R-CHOP
ulcerative colitis (UC)
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Summary:A 47-year-old woman with ulcerative colitis (UC) was admitted to our hospital for renal dysfunction and progressive anemia. Colonoscopy revealed intestinal lesions and pathological findings showed intravascular large B-cell lymphoma (IVLBCL). According to the polymerase chain reaction analysis of sequential rectal specimens, we concluded that she suffered from intestinal BCL, not UC. After chemotherapy, her renal function progressed to nephrotic syndrome. The pathological findings of renal biopsy specimens indicated membranoproliferative glomerulonephritis (MPGN). Chemotherapy was continued and led to the remission of BCL and MPGN. We herein describe the first case of intestinal IVLBCL mimicking UC with secondary MPGN.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.55.6737