Prediction of Infarct Lesion Volumes by Processing Magnetic Resonance Apparent Diffusion Coefficient Maps in Patients with Acute Ischemic Stroke

• Published in: Journal of stroke and cerebrovascular diseases 2016-12, Vol.25 (12), p.2821-2827
• Main Authors: Qian, Qi, MM, Huang, Hai-Tao, MM, Xu, Li, MM, Jin, Ping, MM, Lin, Min, MB
• Format: Article
• Language: English
• Subjects: Acute cerebral infarction; Aged; apparent diffusion coefficient; Area Under Curve; Brain - diagnostic imaging; Brain Infarction - diagnostic imaging; Brain Infarction - etiology; Brain Ischemia - diagnostic imaging; Brain Ischemia - etiology; Cardiovascular; Diffusion Magnetic Resonance Imaging; diffusion-weighted imaging; Female; Humans; Image Interpretation, Computer-Assisted; infarct volume; Logistic Models; magnetic resonance imaging; Male; Middle Aged; Multivariate Analysis; Neurology; Predictive Value of Tests; Prognosis; region of interest; Reproducibility of Results; Risk Factors; ROC Curve; Severity of Illness Index; T1-weighted imaging; T2-weighted imaging
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2016.07.041

Objective We aimed to investigate the diagnostic value of apparent diffusion coefficient (ADC) maps in magnetic resonance imaging (MRI) in the volume of acute cerebral infarction (ACI). Methods A total of 207 ACI patients were selected in our study. The cerebral infarction (CI) volume in the initial diffusion-weighted imaging examination, minimum ADC value, relative apparent diffusion coefficient (rADC) value, and mean ADC value were measured. The correlations between age, smoking, drinking, hypertension, diabetes, coronary heart disease, clinical stage, the lowest ADC value, the mean ADC value, and the mean rADC value with CI volume were analyzed by logistic regression analysis. A receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of the ADC value in the ACI volume. Results There was a significant difference in the distribution of the CI volume in ACI patients ( P  <   .05). A significant difference was found in the signal intensity and percentage distribution of ADC map in patients of different CI groups with different CI volumes ( P  <   .05). The signal of the ADC map was positively correlated with the CI volume. The mean ADC and rADC values had significant differences between different CI volumes (all P  <   .05). Logistic regression analysis revealed that the mean ADC value was significantly correlated with the CI volume ( P  <   .05). Analysis of the ROC curve showed that the quantitative value of ADC has a diagnostic value for the ACI volume. Conclusion This study has shown that the signal intensity change on the ADC map in MRI and quantitative analysis of the ADC value can be used as a reference for predicting the ACI volume.