Association between age and overall survival of patients with hepatocellular carcinoma after hepatic resection

Aim The suitability of hepatic resection for older patients remains controversial. This study aimed to investigate whether age influences overall survival of patients with hepatocellular carcinoma (HCC) after resection. Methods Records of 1,132 patients with HCC after hepatic resection were retrospe...

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Published in:Journal of surgical oncology 2016-12, Vol.114 (8), p.966-970
Main Authors: Tan, Jun-Tao, Zhao, Chang, Peng, Ning-Fu, Yang, Yang, Zhong, Jian-Hong, Yang, Tian, Zheng, Ming-Hua, Wang, Yan-Yan, Gong, Wen-Feng, Xiang, Bang-De, Li, Le-Qun
Format: Article
Language:English
Subjects:
Adult
age
Age Factors
Aged
Aged, 80 and over
Cancer surgery
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Female
Follow-Up Studies
Hepatectomy
hepatic resection
hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Medical prognosis
Middle Aged
overall survival
Prognosis
Retrospective Studies
Risk Factors
Survival Analysis
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Summary:Aim The suitability of hepatic resection for older patients remains controversial. This study aimed to investigate whether age influences overall survival of patients with hepatocellular carcinoma (HCC) after resection. Methods Records of 1,132 patients with HCC after hepatic resection were retrospectively reviewed. Overall survival (OS) was compared between younger and older patients based on five cut‐off ages (30, 40, 50, 60, and 70 years). Results Across all patients, OS was 89.7% at 1 year, 67.7% at 3 years, and 47.7% at 5 years. OS was similar between younger and older patients at all cut‐off ages (all P > 0.1), but OS was marginally lower among patients >70 years old than those ≤70 (P = 0.090). Multivariate analyses identified several risk factors for lower OS: preoperative serum albumin 80 U/L, α‐fetoprotein ≥400 ng/ml, presence of esophagogastric varices or macrovascular invasion, incomplete/absent tumor capsule, tumor size >10 cm, tumor number ≥3, and major hepatectomy. Conclusion Age does not influence the prognosis of patients with HCC after hepatic resection. Older patients should be considered for curative resection if remnant liver volume and liver function are adequate. J. Surg. Oncol. 2016;114:966–970. © 2016 Wiley Periodicals, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24434