Vasculogenic mimicry in malignant mesothelioma: an experimental and immunohistochemical analysis

Vasculogenic mimicry, the process in which cancer cells form angiomatoid structures independent of or in addition to host angiogenesis has been recorded in several otherwise non-endothelial malignant neoplasms. This study describes evidence of routine vascular mimicry by human mesothelioma cell line...

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Bibliographic Details
Published in:Pathology 2016-12, Vol.48 (7), p.650-659
Main Authors: Pulford, Emily, Hocking, Ashleigh, Griggs, Kim, McEvoy, James, Bonder, Claudine, Henderson, Douglas W., Klebe, Sonja
Format: Article
Language:English
Subjects:
angiogenesis
Animals
CD31
Cell Differentiation
Cell Line, Tumor
Coculture Techniques
Endothelial Cells - cytology
Female
Heterografts
Humans
Immunohistochemistry
Male
Melanoma - pathology
mesothelial markers
Mesothelioma
Mice
Mice, Inbred BALB C
Mice, Nude
Neovascularization, Pathologic - pathology
vasculogenic mimicry
VEGF
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Summary:Vasculogenic mimicry, the process in which cancer cells form angiomatoid structures independent of or in addition to host angiogenesis has been recorded in several otherwise non-endothelial malignant neoplasms. This study describes evidence of routine vascular mimicry by human mesothelioma cell lines in vitro, when the cell lines are cultured alone or co-cultured with human umbilical vascular endothelial cells, with the formation of angiomatoid tubular networks. Vasculogenic mimicry is also supported by immunohistochemical demonstration of human-specific anti-mitochondria antibody labelling of tumour-associated vasculature of human mesothelioma cells xenotransplanted into nude mice, and by evidence of vascular mimicry in some biopsy samples of human malignant mesotheliomas. These studies show mosaic interlacing of cells that co-label or label individually for immunohistochemical markers of endothelial and mesothelial differentiation. If vascular mimicry in mesothelioma can be characterised more fully, this may facilitate identification of more specific and targeted therapeutic approaches such as anti-angiogenesis in combination with chemotherapy and immunotherapy or other therapeutic approaches.
ISSN:0031-3025
1465-3931
DOI:10.1016/j.pathol.2016.07.009