Optically Detected Degradation of NaYF4:Yb,Tm-Based Upconversion Nanoparticles in Phosphate Buffered Saline Solution

In a proof-of-concept study, we assessed different analytical and spectroscopic parameters for stability screening of differently sized β-NaYF4:20 mol % Yb3+, 2 mol % Tm3+ upconversion nanoparticles (UCNPs) exemplarily in the bioanalytically relevant buffer phosphate buffered saline (PBS; pH 7.4) at...

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Bibliographic Details
Published in:Langmuir 2017-01, Vol.33 (2), p.553-560
Main Authors: Plohl, Olivija, Kraft, Marco, Kovač, Janez, Belec, Blaž, Ponikvar-Svet, Maja, Würth, Christian, Lisjak, Darja, Resch-Genger, Ute
Format: Article
Language:English
Online Access:Get full text
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Summary:In a proof-of-concept study, we assessed different analytical and spectroscopic parameters for stability screening of differently sized β-NaYF4:20 mol % Yb3+, 2 mol % Tm3+ upconversion nanoparticles (UCNPs) exemplarily in the bioanalytically relevant buffer phosphate buffered saline (PBS; pH 7.4) at 37 and 50 °C. This included the potentiometric determination of the amount of released fluoride ions, surface analysis with X-ray photoelectron spectroscopy (XPS), and steady-state and time-resolved fluorescence measurements. Based on these results, the luminescence lifetime of the 800 nm upconversion emission was identified as an optimum parameter for stability screening of UCNPs and changes in particle surface chemistry.
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.6b03907