An Overview of Epigenetics in Chinese Medicine Researches

Chinese medicine（CM） has contributed to human health care for several thousand years and is still popular in Asian countries. But the mechanisms underlying CM remain obscure, and need to be clarified by modern biological subjects and methods. Recently, CM researches on epigenetics have gained obviou...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2017-09, Vol.23 (9), p.714-720
Main Authors: Hu, Xue-qing, Su, Shi-bing
Format: Article
Language:English
Subjects:
Biomedical Research
DNA甲基化
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Epigenesis, Genetic - drug effects
Humans
Medicine
Medicine & Public Health
Medicine, Chinese Traditional
Review
RNA干扰
Syndrome
中药方剂
亚洲国家
分子生物学技术
现代生物学
表观遗传学
遗传修饰
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Summary:Chinese medicine（CM） has contributed to human health care for several thousand years and is still popular in Asian countries. But the mechanisms underlying CM remain obscure, and need to be clarified by modern biological subjects and methods. Recently, CM researches on epigenetics have gained obvious improvement following rapidly developed molecular technologies. In this review, we revealed mutual characteristics of epigenetics and CM, such as holism, yin-yang dynamic nature, reversibility and balance, and visceral manifestation. Moreover, epigenetic modifications, including DNA methylation, histone post-transcriptional modifications, micro RNA interference, etc. may help explore the molecular basis of CM syndrome classification, and mechanisms of Chinese herbal medicine（CHM）, CHM compounds and Chinese herbal formulae activities. Meanwhile, CM and epigenetics might promote each other and jointly develop following the continuous progress of epigenetics in CM researches.
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-016-2274-y