Interleukin-1β as a driver of renal NGAL production

Neutrophil gelatinase-associated lipocalin (NGAL) is increasingly regarded as a biomarker of acute kidney injury, or kidney injury in general, but the stimuli responsible for its production are incompletely understood. This study tested the relationship between the pro-inflammatory cytokine interleu...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2017-03, Vol.91, p.38-43
Main Authors: Bonnemaison, Mathilde L., Marks, Eileen S., Boesen, Erika I.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - immunology
Acute Kidney Injury - pathology
Animals
Cell Line, Transformed
Humans
Interleukin-1beta - immunology
Interleukin-1β
Kidney
Kidney Tubules, Proximal - immunology
Kidney Tubules, Proximal - pathology
Lipocalin 2
Lipocalin-2 - immunology
Mice
Neutrophil gelatinase-associated lipocalin (NGAL)
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Summary:Neutrophil gelatinase-associated lipocalin (NGAL) is increasingly regarded as a biomarker of acute kidney injury, or kidney injury in general, but the stimuli responsible for its production are incompletely understood. This study tested the relationship between the pro-inflammatory cytokine interleukin-1β (IL-1β) and both circulating and renal NGAL, using chronic subcutaneous infusion of IL-1β in mice and tissue culture of renal cell lines. Following a 14-day subcutaneous infusion of vehicle or IL-1β (10ng/h) in male C57Bl/6 mice, a striking positive correlation (r2=0.94; P30-fold). These data indicate IL-1β serves as a powerful stimulus for renal production of NGAL.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2016.12.004