Toxoplasma gondii : One Organism, Multiple Models

Toxoplasma gondii is an intensely studied protozoan parasite. It is also used as a model organism to research additional clinically relevant human and veterinary parasites due to ease of in vitro culture and genetic manipulation. Recently, it has been developed as a model of inflammatory bowel disea...

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Bibliographic Details
Published in:Trends in parasitology 2017-02, Vol.33 (2), p.113-127
Main Authors: Szabo, Edina K, Finney, Constance A.M
Format: Article
Language:English
Subjects:
Animals
Gastroenterology and Hepatology
Humans
in vitro models
in vivo models
Infectious Disease
Models, Biological
mouse models
parasites
Research - trends
Technology - trends
Toxoplasma
Toxoplasma - physiology
Toxoplasmosis - pathology
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Summary:Toxoplasma gondii is an intensely studied protozoan parasite. It is also used as a model organism to research additional clinically relevant human and veterinary parasites due to ease of in vitro culture and genetic manipulation. Recently, it has been developed as a model of inflammatory bowel disease, due to their similar pathologies. However, researchers vary widely in how they use T. gondii , which makes study comparisons and interpretation difficult. The aim of this review is to provide researchers with a tool to: (i) determine the appropriateness of the different T. gondii models to their research, (ii) interpret results from the wide range of study conditions, and (iii) consider new advances in technology which could improve or refine their experimental setup.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2016.11.007