Gold-Catalyzed Intramolecular Regioselective 7-exo-dig Cyclization To Access 3-Methylene-3,4-dihydrobenzo[b]oxepinones

An efficient gold-catalyzed synthesis of substituted 3-methylene-3,4-dihydrobenzo[b]oxepinones from ortho-O-propargyl substituted aryl enaminones has been achieved. In this transformation a new C-C bond formation occurred regioselectively via 7-exo-dig cyclization. Benzooxepinone derivatives were ob...

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Bibliographic Details
Published in:Organic letters 2017-01, Vol.19 (1), p.282-285
Main Authors: Mangina, N S V M Rao, Kadiyala, Veerabhushanam, Guduru, Ravinder, Goutham, Kommuru, Sridhar, Balasubramanian, Karunakar, Galla V
Format: Article
Language:English
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Summary:An efficient gold-catalyzed synthesis of substituted 3-methylene-3,4-dihydrobenzo[b]oxepinones from ortho-O-propargyl substituted aryl enaminones has been achieved. In this transformation a new C-C bond formation occurred regioselectively via 7-exo-dig cyclization. Benzooxepinone derivatives were obtained in good to excellent yields in a one-pot synthesis at ambient temperature.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b03433