Prediction of fetal growth restriction using estimated fetal weight vs a combined screening model in the third trimester

ABSTRACT Objectives To compare the performance of third‐trimester screening, based on estimated fetal weight centile (EFWc) vs a combined model including maternal baseline characteristics, fetoplacental ultrasound and maternal biochemical markers, for the prediction of small‐for‐gestational‐age (SGA...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2017-11, Vol.50 (5), p.603-611
Main Authors: Miranda, J., Rodriguez‐Lopez, M., Triunfo, S., Sairanen, M., Kouru, H., Parra‐Saavedra, M., Crovetto, F., Figueras, F., Crispi, F., Gratacós, E.
Format: Article
Language:English
Subjects:
Adult
Biochemical markers
Biochemistry
Biomarkers - blood
Birth weight
Blood pressure
Case-Control Studies
estimated fetal weight
Female
fetal biometry
fetal growth restriction
Fetal Growth Retardation - diagnosis
Fetal Weight - physiology
Fetuses
Gestation
Health risk assessment
Humans
Infant, Newborn
Infant, Small for Gestational Age
Inhibin
Lipocalin
Logistic Models
Markers
Mathematical models
Medical screening
Multivariate Analysis
Neonates
Placenta
Prediction models
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, Third - physiology
Prenatal development
Prenatal Diagnosis - methods
Prospective Studies
Regression analysis
screening
Small for gestational age
third‐trimester screening
Ultrasound
Uterus
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Summary:ABSTRACT Objectives To compare the performance of third‐trimester screening, based on estimated fetal weight centile (EFWc) vs a combined model including maternal baseline characteristics, fetoplacental ultrasound and maternal biochemical markers, for the prediction of small‐for‐gestational‐age (SGA) neonates and late‐onset fetal growth restriction (FGR). Methods This was a nested case–control study within a prospective cohort of 1590 singleton gestations undergoing third‐trimester (32 + 0 to 36 + 6 weeks' gestation) evaluation. Maternal baseline characteristics, mean arterial pressure, fetoplacental ultrasound and circulating biochemical markers (placental growth factor (PlGF), lipocalin‐2, unconjugated estriol and inhibin A) were assessed in all women who subsequently delivered a SGA neonate (n = 175), defined as birth weight
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.17393