Impact of Postoperative Morbidity on Long-Term Survival After Resection for Colorectal Liver Metastases

Background Although correlation of postoperative morbidity with long-term survival is recognized to influence long-term survival after other cancer surgery, little information exists about the impact of postoperative morbidity on patient outcomes following liver resection for colorectal metastases....

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Bibliographic Details
Published in:Annals of surgical oncology 2016-12, Vol.23 (Suppl 5), p.929-937
Main Authors: Tanaka, Kuniya, Kumamoto, Takafumi, Nojiri, Kazunori, Matsuyama, Ryusei, Takeda, Kazuhisa, Endo, Itaru
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Colorectal Neoplasms - pathology
Disease-Free Survival
Female
Hepatectomy - adverse effects
Hepatobiliary Tumors
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Postoperative Complications - etiology
Retrospective Studies
Severity of Illness Index
Surgery
Surgical Oncology
Survival Rate
Time Factors
Tumor Burden
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Summary:Background Although correlation of postoperative morbidity with long-term survival is recognized to influence long-term survival after other cancer surgery, little information exists about the impact of postoperative morbidity on patient outcomes following liver resection for colorectal metastases. Methods We studied the impact of postoperative morbidity on long-term survival after liver resection for colorectal cancer metastases using data from 312 patients with curative hepatectomy. Results Among all 312 patients evaluated, 98 complications occurred, affecting 80 patients (26%). The 80 patients with morbidity had a lower disease-free rate ( P  = 0.03), resulting in poor overall survival ( P  = 0.02) compared with the group with no morbidity ( n  = 232). Decreases in disease-free and overall survival also were associated with severity of postoperative complications. When patients were divided according to extent of metastases, little impact of morbidity on overall survival ( P  = 0.10) and disease-free rate ( P  = 0.35) was demonstrated in patients whose metastases were less advanced. However, a negative impact of morbidity compared with no morbidity on disease-free rate ( P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-010-1352-1