Light activated liposomes: Functionality and prospects in ocular drug delivery

Ocular drug delivery, especially to the retina and choroid, is a major challenge in drug development. Liposome technology may be useful in ophthalmology in enabling new routes of delivery, prolongation of drug action and intracellular drug delivery, but drug release from the liposomes should be cont...

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Bibliographic Details
Published in:Journal of controlled release 2016-12, Vol.244 (Pt B), p.157-166
Main Authors: Lajunen, Tatu, Nurmi, Riikka, Kontturi, Leena, Viitala, Lauri, Yliperttula, Marjo, Murtomäki, Lasse, Urtti, Arto
Format: Article
Language:English
Subjects:
Administration, Ophthalmic
Animals
Drug Delivery Systems
Drug release
Eye - metabolism
Humans
Light
Light activation
Liposome
Liposomes - radiation effects
Ocular drug delivery
Posterior segment
Retina
Thermosensitive
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Summary:Ocular drug delivery, especially to the retina and choroid, is a major challenge in drug development. Liposome technology may be useful in ophthalmology in enabling new routes of delivery, prolongation of drug action and intracellular drug delivery, but drug release from the liposomes should be controlled. For that purpose, light activation may be an approach to release drug at specified time and site in the eye. Technical advances have been made in the field of light activated drug release, particularly indocyanine green loaded liposomes are a promising approach with safe materials and effective light triggered release of small and large molecules. This review discusses the liposomal drug delivery with light activated systems in the context of ophthalmic drug delivery challenges. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2016.08.024