Dysfunctional organization of default mode network before memory impairments in type 2 diabetes

Highlights • T2DM exhibited reduced deactivation during episodic memory task with intact memory. • T2DM showed weakened task-related anterior-posterior connectivity within DMN. • T2DM showed decreased network global efficiency of DMN over a wide range of sparsity. • Altered deactivation was negative...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-12, Vol.74, p.141-148
Main Authors: Chen, Yaojing, MS, Liu, Zhen, MS, Wang, Ailin, BS, Zhang, Junying, MD, Zhang, Sisi, BS, Qi, Di, BS, Chen, Kewei, PhD, Zhang, Zhanjun, MD
Format: Article
Language:English
Subjects:
Aged
Alzheimer’s disease
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiopathology
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Connectome - methods
Default mode network
Diabetes Mellitus, Type 2 - complications
Endocrinology & Metabolism
Episodic memory
Female
Functional connectivity
Humans
Magnetic Resonance Imaging
Male
Memory Disorders - diagnostic imaging
Memory Disorders - etiology
Memory Disorders - physiopathology
Memory, Episodic
Middle Aged
Psychiatry
Topological organization
Type 2 diabetes mellitus
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Summary:Highlights • T2DM exhibited reduced deactivation during episodic memory task with intact memory. • T2DM showed weakened task-related anterior-posterior connectivity within DMN. • T2DM showed decreased network global efficiency of DMN over a wide range of sparsity. • Altered deactivation was negatively related with altered connectivity in DMN.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.08.012