Immunological mechanism of wheezing attack in children with cytomegalovirus infection

To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection. A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (...

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Bibliographic Details
Published in:Zhongguo dang dai er ke za zhi 2016-09, Vol.18 (9), p.831-834
Main Authors: Zhu, Xiao-Hua, Chen, Qiang, Li, Qiu-Gen, Li, Lan, Ke, Jiang-Wei, Liu, Zhi-Qiang, Ran, Fei
Format: Article
Language:Chinese
Subjects:
Child, Preschool
Cytokines - blood
Cytomegalovirus Infections - immunology
Female
Humans
Infant
Male
Respiratory Sounds - etiology
Respiratory Sounds - immunology
T-Lymphocytes, Regulatory - immunology
Th17 Cells - immunology
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Summary:To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection. A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group. The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group. Wheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2016.09.009