Dipeptidyl peptidase 9 (DPP9) in human skin cells

Highlights • Keratinocytes and fibroblasts endogenously express DPP9 transcript and protein. • DPP9 is localized mostly in cytoplasm;its sub-localization in Golgi is very scarce. • DPP8/9 enzyme activity was shown in cytosolic fraction of both skin cells types. • DPP8/9 enzyme activity participates...

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Bibliographic Details
Published in:Immunobiology (1979) 2017-02, Vol.222 (2), p.327-342
Main Authors: Gabrilovac, Jelka, PhD, Čupić, Barbara, PhD, Zapletal, Emilija, PhD, Kraus, Ognjen, MD PhD, Jakić-Razumović, Jasminka, MD PhD
Format: Article
Language:English
Subjects:
Adhesion
Advanced Basic Science
Allergy and Immunology
Cell Adhesion - genetics
Cell Movement - genetics
Cell Proliferation - genetics
Cells, Cultured
Child
Child, Preschool
Dipeptidyl peptidase 9 (DPP9)
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism
Enzyme Activation
Enzyme activity
Fibroblasts
Fibroblasts - metabolism
Gene Expression
Gene Silencing
Humans
Intracellular Space
Keratinocytes
Keratinocytes - metabolism
Male
Migration
Proliferation
Protein Transport
Skin - immunology
Skin - metabolism
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Summary:Highlights • Keratinocytes and fibroblasts endogenously express DPP9 transcript and protein. • DPP9 is localized mostly in cytoplasm;its sub-localization in Golgi is very scarce. • DPP8/9 enzyme activity was shown in cytosolic fraction of both skin cells types. • DPP8/9 enzyme activity participates in regulation of the skin cells’ proliferation. • DPP9 participates in regulation of adhesion and/or migration of the skin cells.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2016.09.007