Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients

Highlights • 1146 genes are differentially expressed in schizophrenia. • A strong pattern of differentially expressed immune response genes. • 23 genes are clinically proven drug targets as well as 20 antipsychotic agents. • 16 genes are associated with schizophrenia from the Psychiatric Genomics Co...

Full description

Saved in:
Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.259-265
Main Authors: Voisey, Joanne, Mehta, Divya, McLeay, Robert, Morris, Charles P, Wockner, Leesa F, Noble, Ernest P, Lawford, Bruce R, Young, Ross McD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Brain
DNA Methylation
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Humans
Immune response
Methylation
Prefrontal Cortex - metabolism
Psychiatry
RNA-Seq
Schizophrenia
Schizophrenia - genetics
Schizophrenia - metabolism
Signal Transduction - genetics
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • 1146 genes are differentially expressed in schizophrenia. • A strong pattern of differentially expressed immune response genes. • 23 genes are clinically proven drug targets as well as 20 antipsychotic agents. • 16 genes are associated with schizophrenia from the Psychiatric Genomics Consortium.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.12.006