APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review

The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2018-03, Vol.177 (2), p.126-142
Main Authors: Forero, Diego A., López‐León, Sandra, González‐Giraldo, Yeimy, Dries, Daniel R., Pereira‐Morales, Angela J., Jiménez, Karen M., Franco‐Restrepo, Juan E.
Format: Article
Language:English
Subjects:
Animal models
Animals
Apolipoprotein E
Apolipoproteins E - genetics
Apolipoproteins E - metabolism
Behavior disorders
Brain - metabolism
Brain - pathology
candidate gene
Centenarians
Endophenotypes
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genotype
Humans
Mental disorders
Mental Disorders - genetics
Mental Disorders - metabolism
Mental Disorders - pathology
meta‐analyses
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
neurogenetics
Neurological diseases
neuropsychiatric genetics
Polymorphism, Genetic
Structure-function relationships
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Summary:The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the APOE gene and its relationship with brain disorders. Evidence from genome‐wide association studies and meta‐analyses shows that the APOE gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the APOE gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes. © 2016 Wiley Periodicals, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.32516